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A typical fire ant colony produces large mounds in open areas, and feeds mostly on young plants, seeds, and sometimes crickets. Fire ants often attack small animals and can kill them. Unlike many other ants, which bite and then spray acid on the wound, fire ants bite only to get a grip and then sting (from the abdomen) and inject a toxic alkaloid venom called solenopsin, a compound from the class of piperidines. For humans, this is a painful sting, a sensation similar to what one feels when burned by fire—hence the name fire ant—and the after effects of the sting can be deadly to sensitive individuals. The venom is both insecticidal and antibiotic.

Fire ants nest in the soil, often near moist areas, such as river banks, pond shores, watered lawns and highway shoulder. Usually, the nest will not be visible, as it will be built under objects such as timber, logs, rocks, or bricks. If there is no cover for nesting, dome-shaped mounds will be constructed, but these are usually only found in open spaces, such as fields, parks and lawns. These mounds can reach heights of 40 cm (15.7 in), and can also be as deep as a metre and a half (five feet). [1] Colonies are founded by small groups of queens or single queens. Even if only one queen survives, within a month or so, the colony can expand to thousands of individuals. Some colonies may be polygynous (having multiple queens per nest). A lack of mounds in your yard does not necessarily mean there are no fire ants active. Their mound building is influenced by moisture present in the soil. After a good rain you may notice mound popping up seemingly overnight. Those fire ants were already in your yard.

A fire ant colony can be active in up to two acres of area (think of the size of three football fields combined). Fire ant control can often be accomplished by application of a bait they will take home with them thinking it is food.